When used long term (more than 2-4 weeks) all doses, even the lowest available doses of each benzodiazepine can cause patient injury and require a taper. We have received many reports of patients being injured on doses that are typically regarded in medicine as small, such as .25 milligrams of xanax, .5 milligrams of ativan, 5 milligrams of valium or .125 milligrams of klonopin.